Desloge is a city in St. Francois County, Missouri. The population was 5,054 at the 2010 census.
Desloge is located at 37°52′22″N 90°31′14″W (37.872781, -90.520484). According to the United States Census Bureau, the city has a total area of 2.90 square miles (7.51 km²), all of it land.
As of the census of 2010, there were 5,054 people, 2,092 households, and 1,361 families residing in the city. The population density was 1,742.8 inhabitants per square mile (672.9/km²). There were 2,274 housing units at an average density of 784.1 per square mile (302.7/km²). The racial makeup of the city was 97.37% White, 0.77% Black or African American, 0.24% Native American, 0.16% Asian, 0.06% from other races, and 1.40% from two or more races. Hispanic or Latino of any race were 1.09% of the population.
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