Jefferson County is located in the eastern portion of the state of Missouri. As of the 2010 census, the population was 218,733, making it the sixth-most populous county in Missouri. Its county seat is Hillsboro. The county was organized in 1818 and named in honor of former president Thomas Jefferson. In 1980, according to the U.S. census held that year, the county contained the mean center of U.S. population. Notably, this was the first census in which the center of population was west of the Mississippi River. Jefferson County is part of the St. Louis Metropolitan Statistical Area and encompasses many of the city's southern suburbs.
According to the U.S. Census Bureau, the county has a total area of 664 square miles (1,720 km²), of which 657 square miles (1,700 km²) is land and 7.7 square miles (20 km²) (1.2%) is water. The county's eastern border is the Mississippi River.
As of the 2010 Census Jefferson County had a population of 218,733. The reported ethnic and racial make up of the population was 95.4% non-Hispanic white, 0.8% African-American, 0.3% Native American, 0.6% Asian, 0.4% reporting some other race, 1.3% reporting two or more races and 1.6% Hispanic or Latino of any race.
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